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Zoplicone is a drug that has hypnotic and sedative effects belonging to the group called cyclopyrrolones and is administered orally. Complementarily, it presents a mild anxiolytic activity, myorelaxant and anticonvulsant. It is used for the short term treatment of insomnia. Several studies have shown that Zoplicone as a sleep inducing agent shortens the time of onset of sleep and reduces the incidence of nocturnal arousals, thereby increasing the quality of sleep and wakefulness in the morning.

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Zoplicone is widely spread among people with sleep disorders, particularly insomnia. This reason could explain why more and more people buy Zoplicone online to treat these types of conditions: it is a fast, safe and saves money.

if you buy Zoplicone, you need to know that is a benzodiazepine type BZ1 (benzodiazepine) receptor agonist that is part of the chloroform supramolecular ionophore complex, integrated with the gamma-aminobutyric acid (GABA) receptor. Ultimately, there is an increase in brain activity of GABA, an inhibitory neurotransmitter. Zoplicone shortens the time for the onset of sleep and reduces the incidence of nocturnal awakenings, which increases the quality of sleep and the awakening of the morning. In most cases, only a short-term treatment with this drug is usually required, which should not normally exceed two weeks.

Zoplicone is absorbed rapidly, with its bioavailability of more than 75%. Peak plasma concentrations are reached in less than 2 hours and rise to approximately 30 and 60 ng / mL after administration of 3.75 and 7.5 mg, respectively. Absorption is not modified by feeding or by repetition of doses.

 

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As for the dosage for the short-term treatment of primary insomnia the following scheme is recommended:

Adults: The usual dose is 7.5 mg given before bedtime.

Elderly and / or debilitated patients: a recommended initial dose is 3.75 mg, which may be increased if necessary, to 7.5 mg at bedtime

Treatment with zoplicone should not exceed 7-10 consecutive days. Use for more than 2-3 weeks should require a complete reassessment of the patient.

Because sleep disorders may be the first manifestation of physical or psychiatric problems, symptomatic treatment of insomnia should be initiated only after a careful evaluation of the patient by the specialist.

Zoplicone is contraindicated in patients with nipersensitivity to the active ingredient or to any of the components of its formulation.

Patients should be advised not to perform tasks requiring full attention and / or precise motor coordination, such as handling dangerous machinery or driving vehicles. You can order zoplicone online from several sources over the ingternet. Check first if we are talking about brand or generic types. If you purchase zoplicone online cheap because is generic, just ask what labs made that generic pill. You can buy zoplicone overnight as well, but the matter is the quality of what are you buying and not the speed of the shipping method. If the source offer payment method like credit or debit cards then you are in front of a source that offer real guaranteed about the quality of the product because you can get a refund easily in the case you buy zoplicone online and later you are not satisfied by any reason.

The therapeutic effect of benzodiazepines and related drugs may decrease with repeated use for several weeks. Even if it has not been reported with zoplicone, the tolerance phenomenon must be taken into account, strictly adhering to the maximum treatment time including the period of progressive discontinuation. After four weeks of treatment, the specialist should reassess the need to continue or not to administer the hypnotic.

 

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Zoplicone may develop drug dependence, depending on the duration of treatment, dose, association with other medications (anxiolytics, antipsychotics, hypnotics, etc.) and a history of other drug dependencies, including alcohol. Signs and symptoms consistent with abstinence syndrome have been described in patients treated for a long time and, especially at doses higher than those recommended.

It is recommended that zoplicone be progressively withdrawn in order to minimize the risk of withdrawal symptoms and to alert the patient to the possibility of this, informing the physician if there are manifestations such as headache, insomnia, muscle aches, anxiety, Agitation, confusion, irritation and in severe cases seizures.

The occurrence of a variety of abnormal thoughts and behavioral changes associated with the use of the sedative / hypnotic has been reported. Some of these changes may be characterized by decreased inhibition (eg, aggressiveness and extraversion outside the character), similar to effects produced by alcohol and other CNS depressants.

Visual and auditory hallucinations as well as behavioral changes and complex behaviors have been reported in patients who were not fully awake and who usually do not remember these events.

Alcohol consumption is not recommended, since the sedative effect of zoplicone can be increased. Concomitant administration with CNS depressants may have an additional effect additive. These depressants may be psychotropic medications, analgesics, narcotics, antiepileptic drugs, anesthetics and sedatives antihistamines.

Plasma levels of zoplicone may be increased when co-administered with CYP3A4 inhibitors such as erythromycin, clarithromycin, ketoconazole, itraconazole, and ritonavir. This is because zoplicone is metabolized by the cytochrome P450 isoenzyme CYP3A4. The dose of zoplicone may need to be reduced when co-administered with CYP3A4 inhibitors.

 

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The most common adverse reaction observed with zoplicone is bitter or metallic taste in the mouth.

The following adverse reactions have been reported in patients treated with zoplicone.

– Central nervous system: Common: drowsiness, asthenia, vertigo, confusion, anterograde amnesia and / or deterioration of memory, feeling of drunkenness, euphoria, anxiety or nervousness, depression, abnormalities in coordination, hypotonia, speech disorders. Uncommon: nightmares, agitation, hostility, decreased libido, tremor, muscle spasms, paresthesias. Hallucinations, aggressiveness, irritability, inappropriate behavior possibly associated with amnesia have been reported rarely.

Elderly patients tend to have a higher incidence of palpitations, vomiting, anorexia, sialorrhea, confusion, agitation, anxiety, tremor and sweating than younger patients. Anterograde amnesia is a dose-related phenomenon. Some cases of withdrawal syndrome have been reported after withdrawal of zoplicone.

An important clarification is that zoplicone contains gluten-free wheat starch as an excipient. Celiac patients should consult their physician before using it. Patients with wheat allergy (other than celiac disease) should not take this medicine. This medicine is free of gluten.

Also, special care should be taken for those people who have liver or kidney disorders, have muscle weakness, have other diseases or have allergies.

 

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